Control of fungal sterol C-24 transalkylation: Importance to developmental regulation

W. David Nes, Patrick K. Hanners, Edward J. Parish

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34 Scopus citations


When cultures of Gibberella fujikuroi are incubated with 24-epiiminolanosterol the introduction of a methyl group into sterol side chains at C-24 is blocked inducing a mycelial accumulation of lanosterol and 24-desalkylsterols, i.e., having the cholestane side chain. The altered sterol composition lead to aberrant mycelial membranes resulting in growth inhibition. A compensatory physiological response to the ensuing hyphal death was induction of asexual sporulation. The results are interpreted to imply that regulation of sterol C-24 transalkylation may be a mechanism to mediate life cycle events of fungi.

Original languageEnglish
Pages (from-to)410-415
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - Sep 16 1986


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