Control of fungal sterol C-24 transalkylation: Importance to developmental regulation

W. David Nes; Patrick K. Hanners; Edward J. Parish

doi:10.1016/S0006-291X(86)80006-7

Control of fungal sterol C-24 transalkylation: Importance to developmental regulation

W. David Nes, Patrick K. Hanners, Edward J. Parish

Chemistry and Biochemistry

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34 Scopus citations

Abstract

When cultures of Gibberella fujikuroi are incubated with 24-epiiminolanosterol the introduction of a methyl group into sterol side chains at C-24 is blocked inducing a mycelial accumulation of lanosterol and 24-desalkylsterols, i.e., having the cholestane side chain. The altered sterol composition lead to aberrant mycelial membranes resulting in growth inhibition. A compensatory physiological response to the ensuing hyphal death was induction of asexual sporulation. The results are interpreted to imply that regulation of sterol C-24 transalkylation may be a mechanism to mediate life cycle events of fungi.

Original language	English
Pages (from-to)	410-415
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	139
Issue number	2
DOIs	https://doi.org/10.1016/S0006-291X(86)80006-7
State	Published - Sep 16 1986

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title = "Control of fungal sterol C-24 transalkylation: Importance to developmental regulation",

abstract = "When cultures of Gibberella fujikuroi are incubated with 24-epiiminolanosterol the introduction of a methyl group into sterol side chains at C-24 is blocked inducing a mycelial accumulation of lanosterol and 24-desalkylsterols, i.e., having the cholestane side chain. The altered sterol composition lead to aberrant mycelial membranes resulting in growth inhibition. A compensatory physiological response to the ensuing hyphal death was induction of asexual sporulation. The results are interpreted to imply that regulation of sterol C-24 transalkylation may be a mechanism to mediate life cycle events of fungi.",

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AU - Parish, Edward J.

PY - 1986/9/16

Y1 - 1986/9/16

N2 - When cultures of Gibberella fujikuroi are incubated with 24-epiiminolanosterol the introduction of a methyl group into sterol side chains at C-24 is blocked inducing a mycelial accumulation of lanosterol and 24-desalkylsterols, i.e., having the cholestane side chain. The altered sterol composition lead to aberrant mycelial membranes resulting in growth inhibition. A compensatory physiological response to the ensuing hyphal death was induction of asexual sporulation. The results are interpreted to imply that regulation of sterol C-24 transalkylation may be a mechanism to mediate life cycle events of fungi.

AB - When cultures of Gibberella fujikuroi are incubated with 24-epiiminolanosterol the introduction of a methyl group into sterol side chains at C-24 is blocked inducing a mycelial accumulation of lanosterol and 24-desalkylsterols, i.e., having the cholestane side chain. The altered sterol composition lead to aberrant mycelial membranes resulting in growth inhibition. A compensatory physiological response to the ensuing hyphal death was induction of asexual sporulation. The results are interpreted to imply that regulation of sterol C-24 transalkylation may be a mechanism to mediate life cycle events of fungi.

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Control of fungal sterol C-24 transalkylation: Importance to developmental regulation

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