TY - JOUR
T1 - Constituents of Chrysothamnus viscidiflorus
AU - Ahmed, Ahmed A.
AU - Hegazy, Mohamed Elamir F.
AU - Hassan, Nahed M.
AU - Wojcinska, Malgorzata
AU - Karchesy, Joe
AU - Pare, Paul W.
AU - Mabry, Tom J.
N1 - Funding Information:
The work was supported by The Robert Welch Foundation at The University of Texas at Austin (Grant F-130) and at Texas Tech University (Grant D-1478). A.A. Ahmed thanks the Alexander von Humboldt Stiftung for the financial support for an HPLC instrument. The authors thank B.G., Dr. Sanders, Department of Zoology, the University of Texas at Austin, TX, USA, for the anti-cancer test.
PY - 2006/7
Y1 - 2006/7
N2 - A phytochemical investigation of the aerial parts of Chrysothamnus viscidiflorus var. viscidiflorus afforded three new [chrysothol (1), 2 and 4] and seven known compounds, including five sesquiterpenes, two cinnamic acid derivatives, two ketoalcohol derivatives and one coumarin glucoside. The structures of two previously reported compounds, 1b and 1c, were revised on the basis of chemical reaction. Structures of the compounds were determined by extensive NMR studies, including DEPT, COSY, NOE, HMQC, HMBC and X-ray analysis. The unpublished X-ray data of the known compounds 6 and 7 are reported. Compounds chrysothol (1), and 8-10 showed anti-cancer activity against human breast cancer cells.
AB - A phytochemical investigation of the aerial parts of Chrysothamnus viscidiflorus var. viscidiflorus afforded three new [chrysothol (1), 2 and 4] and seven known compounds, including five sesquiterpenes, two cinnamic acid derivatives, two ketoalcohol derivatives and one coumarin glucoside. The structures of two previously reported compounds, 1b and 1c, were revised on the basis of chemical reaction. Structures of the compounds were determined by extensive NMR studies, including DEPT, COSY, NOE, HMQC, HMBC and X-ray analysis. The unpublished X-ray data of the known compounds 6 and 7 are reported. Compounds chrysothol (1), and 8-10 showed anti-cancer activity against human breast cancer cells.
KW - Anti-cancer activity
KW - Asteraceae
KW - Chrysothamnus viscidiflorus var. viscidiflorus
KW - Coumarin glucoside
KW - Guaiane sesquiterepene
KW - Sesquiterpenoid glucoside
KW - p-Coumaric acid derivatives
UR - http://www.scopus.com/inward/record.url?scp=33746228235&partnerID=8YFLogxK
U2 - 10.1016/j.phytochem.2006.03.021
DO - 10.1016/j.phytochem.2006.03.021
M3 - Article
C2 - 16808933
AN - SCOPUS:33746228235
SN - 0031-9422
VL - 67
SP - 1547
EP - 1553
JO - Phytochemistry
JF - Phytochemistry
IS - 14
ER -