Cone electrospinning polycaprolactone / collagen scaffolds with microstructure gradient

John Nowlin, Md Maksudul Islam, Yingge Zhou, George Z. Tan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Polycaprolactone (PCL) is a synthetic biomaterial that has been widely used for tissue engineering scaffolds. Collagen, a natural polymer found in various tissues in the human body, can be electrospun in combination with PCL to improve the scaffold's biological characteristics for cell attachment, growth and differentiation. Recreating the physical structure which mimics the extracellular matrix of musculoskeletal tissues generally requires fibrous patterns, including aligned, random, or a mixture of both to form a gradient structure. This study introduced a novel cone rotation electrospinning technique for nanofiber scaffold with microstructure gradient. The effects of key process parameters on nanofiber attributes were evaluated through a factorial design of experiment. We found that changing the rotation speed, electrospinning distance, and position on the cone had significant effects on the structure gradient of nanofiber mats. This cone rotation technique extends the capability of conventional electrospinning to create tunable anisotropic nanofiber scaffolds as potential biomimetic solutions for tissue regeneration.

Original languageEnglish
Title of host publicationProcesses; Materials
PublisherAmerican Society of Mechanical Engineers (ASME)
ISBN (Electronic)9780791858752
DOIs
StatePublished - Jan 1 2019
EventASME 2019 14th International Manufacturing Science and Engineering Conference, MSEC 2019 - Erie, United States
Duration: Jun 10 2019Jun 14 2019

Publication series

NameASME 2019 14th International Manufacturing Science and Engineering Conference, MSEC 2019
Volume2

Conference

ConferenceASME 2019 14th International Manufacturing Science and Engineering Conference, MSEC 2019
CountryUnited States
CityErie
Period06/10/1906/14/19

Keywords

  • Cone electrospinning
  • Microstructure gradient
  • Musculoskeletal tissue engineering
  • Nanofiber scaffold
  • PCL-collagen

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  • Cite this

    Nowlin, J., Islam, M. M., Zhou, Y., & Tan, G. Z. (2019). Cone electrospinning polycaprolactone / collagen scaffolds with microstructure gradient. In Processes; Materials (ASME 2019 14th International Manufacturing Science and Engineering Conference, MSEC 2019; Vol. 2). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/MSEC2019-2871