TY - GEN
T1 - Computational investigation of tissue and blood vessel growth tradeoffs in hierarchical lattices
AU - Arefin, Amit M.E.
AU - Egan, Paul F.
N1 - Publisher Copyright:
Copyright © 2021 by ASME.
PY - 2021
Y1 - 2021
N2 - Computational design is growing in necessity for advancing biomedical technologies, particularly when considering complex systems with numerous trade-offs among design decisions and resulting biomechanical behavior. In tissue engineering applications, porous bone scaffold structures enabled by 3D printing can have intricate lattice structures and hierarchical features that mimic the biological hierarchy of natural bone. However, these hierarchies create challenges in predicting the tissue regeneration process and how different scales of the hierarchy drive varied biological behaviors. Smaller pores facilitate tissue growth while larger pores are necessary for blood vessel growth, however, identifying favorable trade-offs to maximize growth of both tissue and blood vessels remains a challenge, especially for complex 3D printed structures. Here, we adapt tissue and blood vessel growth models for predicting biological growth in scaffolds with varied combinations of beam diameter size, unit cell topology, and hierarchical pore size/distribution. Findings demonstrate that on a normalized scale lattices with no large voids provide greater tissue growth but less blood vessel growth in comparison to lattice layouts with large void areas. A lattice with large void channels provided the greatest blood vessel growth but poorer tissue growth, while a lattice with evenly distributed large voids provided a better compromise between the two types of growth. Overall, these findings demonstrate the merit in computational investigations for design trade-off comparisons in tissue scaffolds, and provide a foundation for future explorations of biological design decisions for regenerative medicine and 3D printed systems.
AB - Computational design is growing in necessity for advancing biomedical technologies, particularly when considering complex systems with numerous trade-offs among design decisions and resulting biomechanical behavior. In tissue engineering applications, porous bone scaffold structures enabled by 3D printing can have intricate lattice structures and hierarchical features that mimic the biological hierarchy of natural bone. However, these hierarchies create challenges in predicting the tissue regeneration process and how different scales of the hierarchy drive varied biological behaviors. Smaller pores facilitate tissue growth while larger pores are necessary for blood vessel growth, however, identifying favorable trade-offs to maximize growth of both tissue and blood vessels remains a challenge, especially for complex 3D printed structures. Here, we adapt tissue and blood vessel growth models for predicting biological growth in scaffolds with varied combinations of beam diameter size, unit cell topology, and hierarchical pore size/distribution. Findings demonstrate that on a normalized scale lattices with no large voids provide greater tissue growth but less blood vessel growth in comparison to lattice layouts with large void areas. A lattice with large void channels provided the greatest blood vessel growth but poorer tissue growth, while a lattice with evenly distributed large voids provided a better compromise between the two types of growth. Overall, these findings demonstrate the merit in computational investigations for design trade-off comparisons in tissue scaffolds, and provide a foundation for future explorations of biological design decisions for regenerative medicine and 3D printed systems.
UR - http://www.scopus.com/inward/record.url?scp=85119993740&partnerID=8YFLogxK
U2 - 10.1115/DETC2021-70739
DO - 10.1115/DETC2021-70739
M3 - Conference contribution
AN - SCOPUS:85119993740
T3 - Proceedings of the ASME Design Engineering Technical Conference
BT - 47th Design Automation Conference (DAC)
PB - American Society of Mechanical Engineers (ASME)
T2 - 47th Design Automation Conference, DAC 2021, Held as Part of the ASME 2021 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC-CIE 2021
Y2 - 17 August 2021 through 19 August 2021
ER -