TY - JOUR
T1 - Comparison of Cardiovascular Pathology in Animal Models of SARS-CoV-2 Infection
T2 - Recommendations Regarding Standardization of Research Methods
AU - Gabrielson, Kathleen
AU - Myers, Stephanie
AU - Yi, Jena
AU - Gabrielson, Edward
AU - Jimenez, Isabel A.
N1 - Publisher Copyright:
Copyright 2023 by the American Association for Laboratory Animal Science.
PY - 2023/2/1
Y1 - 2023/2/1
N2 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged as the viral pathogen that led to the global COVID-19 pandemic that began in late 2019. Because SARS-CoV-2 primarily causes a respiratory disease, much research conducted to date has focused on the respiratory system. However, SARS-CoV-2 infection also affects other organ systems, including the cardiovascular system. In this critical analysis of published data, we evaluate the evidence of cardiovascular pathology in human patients and animals. Overall, we find that the presence or absence of cardiovascular pathology is reported infrequently in both human autopsy studies and animal models of SARS-CoV-2 infection. Moreover, in those studies that have reported cardiovascular pathology, we identified issues in their design and execution that reduce confidence in the conclusions regarding SARS-CoV-2 infection as a cause of significant cardiovascular pathology. Throughout this overview, we expand on these limitations and provide recommendations to ensure a high level of scientific rigor and reproducibility.
AB - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged as the viral pathogen that led to the global COVID-19 pandemic that began in late 2019. Because SARS-CoV-2 primarily causes a respiratory disease, much research conducted to date has focused on the respiratory system. However, SARS-CoV-2 infection also affects other organ systems, including the cardiovascular system. In this critical analysis of published data, we evaluate the evidence of cardiovascular pathology in human patients and animals. Overall, we find that the presence or absence of cardiovascular pathology is reported infrequently in both human autopsy studies and animal models of SARS-CoV-2 infection. Moreover, in those studies that have reported cardiovascular pathology, we identified issues in their design and execution that reduce confidence in the conclusions regarding SARS-CoV-2 infection as a cause of significant cardiovascular pathology. Throughout this overview, we expand on these limitations and provide recommendations to ensure a high level of scientific rigor and reproducibility.
UR - http://www.scopus.com/inward/record.url?scp=85149999050&partnerID=8YFLogxK
U2 - 10.30802/AALAS-CM-22-000095
DO - 10.30802/AALAS-CM-22-000095
M3 - Article
C2 - 36731878
AN - SCOPUS:85149999050
SN - 1532-0820
VL - 73
SP - 58
EP - 71
JO - Comparative Medicine
JF - Comparative Medicine
IS - 1
ER -