Comparative Evaluation of Electroporative Cellular Flows Due to Monopolar and Bipolar Nanosecond, High-Intensity Pulses

Qin Hu; Ravindra Joshi

doi:10.1063/1.4994310

Comparative Evaluation of Electroporative Cellular Flows Due to Monopolar and Bipolar Nanosecond, High-Intensity Pulses

Qin Hu, Ravindra Joshi

Electrical and Computer Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

Electric pulse driven membrane poration finds applications in the fields of biomedical engineering and drug/gene delivery. Here we focus on nanosecond, high-intensity electroporation and probe the role of pulse shape (e.g., monopolar-vs-bipolar), multiple electrode scenarios, and serial-versus-simultaneous pulsing, based on a three-dimensional time-dependent continuum model in a systematic fashion. Our results indicate that monopolar pulsing always leads to higher and stronger cellular uptake. This prediction is in agreement with experimental reports and observations. It is also demonstrated that multipronged electrode configurations influence and increase the degree of cellular uptake.

Original language	English
Pages (from-to)	034701 (1-8)
Journal	Journal of Applied Physics
DOIs	https://doi.org/10.1063/1.4994310
State	Published - Jul 19 2017

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title = "Comparative Evaluation of Electroporative Cellular Flows Due to Monopolar and Bipolar Nanosecond, High-Intensity Pulses",

abstract = "Electric pulse driven membrane poration finds applications in the fields of biomedical engineering and drug/gene delivery. Here we focus on nanosecond, high-intensity electroporation and probe the role of pulse shape (e.g., monopolar-vs-bipolar), multiple electrode scenarios, and serial-versus-simultaneous pulsing, based on a three-dimensional time-dependent continuum model in a systematic fashion. Our results indicate that monopolar pulsing always leads to higher and stronger cellular uptake. This prediction is in agreement with experimental reports and observations. It is also demonstrated that multipronged electrode configurations influence and increase the degree of cellular uptake.",

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N2 - Electric pulse driven membrane poration finds applications in the fields of biomedical engineering and drug/gene delivery. Here we focus on nanosecond, high-intensity electroporation and probe the role of pulse shape (e.g., monopolar-vs-bipolar), multiple electrode scenarios, and serial-versus-simultaneous pulsing, based on a three-dimensional time-dependent continuum model in a systematic fashion. Our results indicate that monopolar pulsing always leads to higher and stronger cellular uptake. This prediction is in agreement with experimental reports and observations. It is also demonstrated that multipronged electrode configurations influence and increase the degree of cellular uptake.

AB - Electric pulse driven membrane poration finds applications in the fields of biomedical engineering and drug/gene delivery. Here we focus on nanosecond, high-intensity electroporation and probe the role of pulse shape (e.g., monopolar-vs-bipolar), multiple electrode scenarios, and serial-versus-simultaneous pulsing, based on a three-dimensional time-dependent continuum model in a systematic fashion. Our results indicate that monopolar pulsing always leads to higher and stronger cellular uptake. This prediction is in agreement with experimental reports and observations. It is also demonstrated that multipronged electrode configurations influence and increase the degree of cellular uptake.

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DO - 10.1063/1.4994310

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