Abstract
Electric pulse driven membrane poration finds applications in the fields of biomedical engineering and
drug/gene delivery. Here we focus on nanosecond, high-intensity electroporation and probe the role of
pulse shape (e.g., monopolar-vs-bipolar), multiple electrode scenarios, and serial-versus-simultaneous
pulsing, based on a three-dimensional time-dependent continuum model in a systematic fashion. Our
results indicate that monopolar pulsing always leads to higher and stronger cellular uptake. This prediction
is in agreement with experimental reports and observations. It is also demonstrated that multipronged
electrode configurations influence and increase the degree of cellular uptake.
Original language | English |
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Pages (from-to) | 034701 (1-8) |
Journal | Journal of Applied Physics |
DOIs | |
State | Published - Jul 19 2017 |