Comparative dietary toxicity of D- and L-selenomethionine in Fisher 344 rats: Brief report

J. R. Hermann, J. E. Spallholz, A. Raferty, S. Gunasegarum

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Five groups of weanling female Fisher 344 rats were fed ad libitum, a commercial control diet with added selenium (Se) as sodium selenite at 16 ppm Se or D- or L-selenomethionine at 10 and 16 ppm Se (15 animals per group). After 8 weeks representative animals were weighed, sacrificed, and tissue samples were fixed in formalin for histological examination or frozen for Se analysis. Final body weights of rats fed 16 ppm Se as selenite, or as D- or L-selenomethionine were significantly reduced compared to controls. Animals fed L-selenomethionine at 16 ppm Se had the greatest reduction in final body weight. Histological toxicity was only observed in animals fed 16 ppm Se as L-selenomethionine or sodium selenite. Toxicity of L-selenomethionine at 16 ppm Se was similar to 16 ppm Se sodium selenite and appeared to be more toxic than D-selenomethionine at 16 ppm Se.

Original languageEnglish
Pages (from-to)69-71
Number of pages3
JournalJournal of Trace Elements in Experimental Medicine
Volume4
Issue number1
StatePublished - 1991

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