Combined whole-body vibration training and L-Citrulline supplementation improves pressure wave reflection in obese postmenopausal women

Alexei Wong, Stacey Alvarez Alvarado, Salvador J. Jaime, Amber W. Kinsey, Maria T. Spicer, Takudzwa A. Madzima, Arturo Figueroa

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Postmenopausal women have increased wave reflection (augmentation pressure (AP) and index (AIx)) and reduced muscle function that predispose them to cardiac diseases and disability. Our aim was to examine the combined and independent effects of whole-body vibration training (WBVT) andL-citrulline supplementation on aortic hemodynamics and plasma nitric oxide metabolites (NOx) in postmenopausal women. Forty-one obese postmenopausal women were randomized to 3 groups:L-citrulline, WBVT+L-citrulline and WBVT+Placebo for 8 weeks. Brachial and aortic systolic blood pressure, diastolic blood pressure, AP, AIx, AIx adjusted to 75 beats/min (AIx@75), and NOx were measured before and after 8 weeks. All groups similarly decreased (P < 0.05) brachial and aortic pressures as well as AP, and similarly increased (P < 0.05) NOx levels. AIx and AIx@75 decreased (P < 0.01) in the WBVT+L-citrulline and WBVT+Placebo groups, but not in the L-citrulline group. The improvement in AIx@75 (−10.5% ± 8.8%, P < 0.05) in the WBVT+L-citrulline group was significant compared with the L-citrulline group.L-Citrulline supplementation and WBVT alone and combined decreased blood pressures. The combined intervention reduced AIx@75. This study supports the effectiveness of WBVT+L-citrulline as a potential intervention for prevention of hypertension-related cardiac diseases in obese postmenopausal women.

Original languageEnglish
Pages (from-to)292-297
Number of pages6
JournalApplied Physiology, Nutrition and Metabolism
Volume41
Issue number3
DOIs
StatePublished - Nov 12 2015

Keywords

  • Aortic blood pressure
  • L-citrulline
  • Postmenopausal women
  • Wave reflection
  • Whole-body vibration

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