TY - JOUR
T1 - Combined whole-body vibration training and L-Citrulline supplementation improves pressure wave reflection in obese postmenopausal women
AU - Wong, Alexei
AU - Alvarez Alvarado, Stacey
AU - Jaime, Salvador J.
AU - Kinsey, Amber W.
AU - Spicer, Maria T.
AU - Madzima, Takudzwa A.
AU - Figueroa, Arturo
N1 - Publisher Copyright:
© 2016 National Research Council of Canada, All rights reserved.
PY - 2015/11/12
Y1 - 2015/11/12
N2 - Postmenopausal women have increased wave reflection (augmentation pressure (AP) and index (AIx)) and reduced muscle function that predispose them to cardiac diseases and disability. Our aim was to examine the combined and independent effects of whole-body vibration training (WBVT) andL-citrulline supplementation on aortic hemodynamics and plasma nitric oxide metabolites (NOx) in postmenopausal women. Forty-one obese postmenopausal women were randomized to 3 groups:L-citrulline, WBVT+L-citrulline and WBVT+Placebo for 8 weeks. Brachial and aortic systolic blood pressure, diastolic blood pressure, AP, AIx, AIx adjusted to 75 beats/min (AIx@75), and NOx were measured before and after 8 weeks. All groups similarly decreased (P < 0.05) brachial and aortic pressures as well as AP, and similarly increased (P < 0.05) NOx levels. AIx and AIx@75 decreased (P < 0.01) in the WBVT+L-citrulline and WBVT+Placebo groups, but not in the L-citrulline group. The improvement in AIx@75 (−10.5% ± 8.8%, P < 0.05) in the WBVT+L-citrulline group was significant compared with the L-citrulline group.L-Citrulline supplementation and WBVT alone and combined decreased blood pressures. The combined intervention reduced AIx@75. This study supports the effectiveness of WBVT+L-citrulline as a potential intervention for prevention of hypertension-related cardiac diseases in obese postmenopausal women.
AB - Postmenopausal women have increased wave reflection (augmentation pressure (AP) and index (AIx)) and reduced muscle function that predispose them to cardiac diseases and disability. Our aim was to examine the combined and independent effects of whole-body vibration training (WBVT) andL-citrulline supplementation on aortic hemodynamics and plasma nitric oxide metabolites (NOx) in postmenopausal women. Forty-one obese postmenopausal women were randomized to 3 groups:L-citrulline, WBVT+L-citrulline and WBVT+Placebo for 8 weeks. Brachial and aortic systolic blood pressure, diastolic blood pressure, AP, AIx, AIx adjusted to 75 beats/min (AIx@75), and NOx were measured before and after 8 weeks. All groups similarly decreased (P < 0.05) brachial and aortic pressures as well as AP, and similarly increased (P < 0.05) NOx levels. AIx and AIx@75 decreased (P < 0.01) in the WBVT+L-citrulline and WBVT+Placebo groups, but not in the L-citrulline group. The improvement in AIx@75 (−10.5% ± 8.8%, P < 0.05) in the WBVT+L-citrulline group was significant compared with the L-citrulline group.L-Citrulline supplementation and WBVT alone and combined decreased blood pressures. The combined intervention reduced AIx@75. This study supports the effectiveness of WBVT+L-citrulline as a potential intervention for prevention of hypertension-related cardiac diseases in obese postmenopausal women.
KW - Aortic blood pressure
KW - L-citrulline
KW - Postmenopausal women
KW - Wave reflection
KW - Whole-body vibration
UR - http://www.scopus.com/inward/record.url?scp=84959261940&partnerID=8YFLogxK
U2 - 10.1139/apnm-2015-0465
DO - 10.1139/apnm-2015-0465
M3 - Article
C2 - 26863234
AN - SCOPUS:84959261940
SN - 1715-5312
VL - 41
SP - 292
EP - 297
JO - Applied Physiology, Nutrition and Metabolism
JF - Applied Physiology, Nutrition and Metabolism
IS - 3
ER -