Combined Effects of Eicosapentaenoic Acid and Adipocyte-Renin Angiotensin System Inhibition on Breast Cancer Cell Inflammation and Migration

Rasha Fahmida; Chanaka Kahathuduwa; Latha Ramalingam; Arelys Hernandez; Hanna Moussa; Naima Moustaid-Moussa

doi:10.3390/cancers

Combined Effects of Eicosapentaenoic Acid and Adipocyte-Renin Angiotensin System Inhibition on Breast Cancer Cell Inflammation and Migration

Rasha Fahmida, Chanaka Kahathuduwa, Latha Ramalingam, Arelys Hernandez, Hanna Moussa, Naima Moustaid-Moussa

Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Obesityisamajorriskfactorforbreastcancer(BC).Obesity-relatedmetabolicalterationssuch asinﬂammationandoveractivationoftheadiposerenin–angiotensinsystem(RAS)maycontributeto theprogressionofBC.Clinicallyusedantihypertensivedrugssuchasangiotensin-convertingenzyme inhibitors (ACE-I) and dietary bioactive components such as eicosapentaenoic acid (EPA) are known for their anti-inﬂammatory and adipose RAS blocking properties. However, whether EPA enhances the protective eﬀects of ACE-I in lessening adipocyte inﬂammation on BC cells has not been studied. WehypothesizedthatcombinedEPAandACE-IwouldattenuateBCcellinﬂammationandmigration possibly via adipose RAS inhibition. To test our hypothesis, we examined the (i) direct eﬀects of an ACE-I (captopril (CAP)) or EPA, individually and combined, on MCF-7 and MDA-MB-231 human BC cells, and the (ii) eﬀects of conditioned medium (CM) from human adipocytes pretreated with the abovementioned agents on BC cells. We demonstrated that CM from adipocytes pr

Original language	English
Pages (from-to)	17
Journal	Cancers
DOIs	https://doi.org/10.3390/cancers
State	Published - Jan 2020

Access to Document

10.3390/cancers

Cite this

@article{838a64e957d345e58675bf33e4d6693e,

title = "Combined Effects of Eicosapentaenoic Acid and Adipocyte-Renin Angiotensin System Inhibition on Breast Cancer Cell Inflammation and Migration",

abstract = "Obesityisamajorriskfactorforbreastcancer(BC).Obesity-relatedmetabolicalterationssuch asinﬂammationandoveractivationoftheadiposerenin–angiotensinsystem(RAS)maycontributeto theprogressionofBC.Clinicallyusedantihypertensivedrugssuchasangiotensin-convertingenzyme inhibitors (ACE-I) and dietary bioactive components such as eicosapentaenoic acid (EPA) are known for their anti-inﬂammatory and adipose RAS blocking properties. However, whether EPA enhances the protective eﬀects of ACE-I in lessening adipocyte inﬂammation on BC cells has not been studied. WehypothesizedthatcombinedEPAandACE-IwouldattenuateBCcellinﬂammationandmigration possibly via adipose RAS inhibition. To test our hypothesis, we examined the (i) direct eﬀects of an ACE-I (captopril (CAP)) or EPA, individually and combined, on MCF-7 and MDA-MB-231 human BC cells, and the (ii) eﬀects of conditioned medium (CM) from human adipocytes pretreated with the abovementioned agents on BC cells. We demonstrated that CM from adipocytes pr",

author = "Rasha Fahmida and Chanaka Kahathuduwa and Latha Ramalingam and Arelys Hernandez and Hanna Moussa and Naima Moustaid-Moussa",

year = "2020",

month = jan,

doi = "10.3390/cancers",

language = "English",

pages = "17",

journal = "Cancers",

publisher = "MDPI Open Access",

}

TY - JOUR

T1 - Combined Effects of Eicosapentaenoic Acid and Adipocyte-Renin Angiotensin System Inhibition on Breast Cancer Cell Inflammation and Migration

AU - Fahmida, Rasha

AU - Kahathuduwa, Chanaka

AU - Ramalingam, Latha

AU - Hernandez, Arelys

AU - Moussa, Hanna

AU - Moustaid-Moussa, Naima

PY - 2020/1

Y1 - 2020/1

N2 - Obesityisamajorriskfactorforbreastcancer(BC).Obesity-relatedmetabolicalterationssuch asinﬂammationandoveractivationoftheadiposerenin–angiotensinsystem(RAS)maycontributeto theprogressionofBC.Clinicallyusedantihypertensivedrugssuchasangiotensin-convertingenzyme inhibitors (ACE-I) and dietary bioactive components such as eicosapentaenoic acid (EPA) are known for their anti-inﬂammatory and adipose RAS blocking properties. However, whether EPA enhances the protective eﬀects of ACE-I in lessening adipocyte inﬂammation on BC cells has not been studied. WehypothesizedthatcombinedEPAandACE-IwouldattenuateBCcellinﬂammationandmigration possibly via adipose RAS inhibition. To test our hypothesis, we examined the (i) direct eﬀects of an ACE-I (captopril (CAP)) or EPA, individually and combined, on MCF-7 and MDA-MB-231 human BC cells, and the (ii) eﬀects of conditioned medium (CM) from human adipocytes pretreated with the abovementioned agents on BC cells. We demonstrated that CM from adipocytes pr

AB - Obesityisamajorriskfactorforbreastcancer(BC).Obesity-relatedmetabolicalterationssuch asinﬂammationandoveractivationoftheadiposerenin–angiotensinsystem(RAS)maycontributeto theprogressionofBC.Clinicallyusedantihypertensivedrugssuchasangiotensin-convertingenzyme inhibitors (ACE-I) and dietary bioactive components such as eicosapentaenoic acid (EPA) are known for their anti-inﬂammatory and adipose RAS blocking properties. However, whether EPA enhances the protective eﬀects of ACE-I in lessening adipocyte inﬂammation on BC cells has not been studied. WehypothesizedthatcombinedEPAandACE-IwouldattenuateBCcellinﬂammationandmigration possibly via adipose RAS inhibition. To test our hypothesis, we examined the (i) direct eﬀects of an ACE-I (captopril (CAP)) or EPA, individually and combined, on MCF-7 and MDA-MB-231 human BC cells, and the (ii) eﬀects of conditioned medium (CM) from human adipocytes pretreated with the abovementioned agents on BC cells. We demonstrated that CM from adipocytes pr

U2 - 10.3390/cancers

DO - 10.3390/cancers

M3 - Article

SP - 17

JO - Cancers

JF - Cancers

ER -

Combined Effects of Eicosapentaenoic Acid and Adipocyte-Renin Angiotensin System Inhibition on Breast Cancer Cell Inflammation and Migration

Abstract

Access to Document

Fingerprint

Cite this