Combined Effects of Eicosapentaenoic Acid and Adipocyte-Renin Angiotensin System Inhibition on Breast Cancer Cell Inflammation and Migration

Rasha Fahmida, Chanaka Kahathuduwa, Latha Ramalingam, Arelys Hernandez, Hanna Moussa, Naima Moustaid-Moussa

Research output: Contribution to journalArticlepeer-review

Abstract

Obesityisamajorriskfactorforbreastcancer(BC).Obesity-relatedmetabolicalterationssuch asinflammationandoveractivationoftheadiposerenin–angiotensinsystem(RAS)maycontributeto theprogressionofBC.Clinicallyusedantihypertensivedrugssuchasangiotensin-convertingenzyme inhibitors (ACE-I) and dietary bioactive components such as eicosapentaenoic acid (EPA) are known for their anti-inflammatory and adipose RAS blocking properties. However, whether EPA enhances the protective effects of ACE-I in lessening adipocyte inflammation on BC cells has not been studied. WehypothesizedthatcombinedEPAandACE-IwouldattenuateBCcellinflammationandmigration possibly via adipose RAS inhibition. To test our hypothesis, we examined the (i) direct effects of an ACE-I (captopril (CAP)) or EPA, individually and combined, on MCF-7 and MDA-MB-231 human BC cells, and the (ii) effects of conditioned medium (CM) from human adipocytes pretreated with the abovementioned agents on BC cells. We demonstrated that CM from adipocytes pr
Original languageEnglish
Pages (from-to)17
JournalCancers
DOIs
StatePublished - Jan 2020

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