Abstract
An operationally convenient and general method for hydroboration of alkenes, aldehydes, and ketones employing Co(acac) 3 as a precatalyst is reported. The hydroboration of alkenes in the presence of HBpin, PPh 3 , and NaO t Bu affords good to excellent yields with high Markovnikov selectivity with up to 97:3 branched/linear selectivity. Moreover, Co(acac) 3 could be used effectively to hydroborate aldehydes and ketones in the absence of additives under mild reaction conditions. Inter- and intramolecular chemoselective reduction of the aldehyde group took place over the ketone functional group.
Original language | English |
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Pages (from-to) | 6695-6700 |
Number of pages | 6 |
Journal | Organic Letters |
Volume | 20 |
Issue number | 21 |
DOIs | |
State | Published - Nov 2 2018 |