Cobalt-Catalyzed Decarboxylative 2-Benzoylation of Oxazoles and Thiazoles with α-Oxocarboxylic Acids

Ke Yang, Xinyong Chen, Yuqi Wang, Wanqing Li, Adnan A. Kadi, Hoong Kun Fun, Hao Sun, Yan Zhang, Guigen Li, Hongjian Lu

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Cobalt-catalyzed decarboxylative cross-coupling of oxazoles and thiazoles with α-oxocarboxylic acids was developed through an sp2 C-H bond functionalization process. This work represents the first example of cobalt-catalyzed decarboxylative C-H bond functionalization and provides an efficient means of building some important bioactive heteroaryl ketone derivatives.

Original languageEnglish
Pages (from-to)11065-11072
Number of pages8
JournalJournal of Organic Chemistry
Volume80
Issue number21
DOIs
StatePublished - Nov 6 2015

Fingerprint Dive into the research topics of 'Cobalt-Catalyzed Decarboxylative 2-Benzoylation of Oxazoles and Thiazoles with α-Oxocarboxylic Acids'. Together they form a unique fingerprint.

Cite this