Cobalt-Catalyzed C(sp2)−H Methylation by using Dicumyl Peroxide as both the Methylating Reagent and Hydrogen Acceptor

Qun Li, Yanrong Li, Weipeng Hu, Renjian Hu, Guigen Li, Hongjian Lu

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

The first cobalt-catalyzed direct methylation of a C(sp2)−H bond using dicumyl peroxide (DCP) as both the methylating reagent and hydrogen acceptor has been established. The reaction proceeded without the use of any additives, and was proven to be applicable to various amides bearing a 2-pyridinylisopropyl (PIP) directing group, providing an efficient access to o-methyl aryl amides with high functional-group tolerance. Preliminary mechanistic studies suggest a radical process would be involved in the catalytic process.

Original languageEnglish
Pages (from-to)12286-12289
Number of pages4
JournalChemistry - A European Journal
Volume22
Issue number35
DOIs
StatePublished - 2016

Keywords

  • C−H functionalization
  • amides
  • cobalt
  • methylation
  • peroxide

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