Abstract
The first cobalt-catalyzed direct methylation of a C(sp(2))-H bond using
dicumyl peroxide (DCP) as both the methylating reagent and hydrogen
acceptor has been established. The reaction proceeded without the use of
any additives, and was proven to be applicable to various amides bearing
a 2-pyridinylisopropyl (PIP) directing group, providing an efficient
access to o-methyl aryl amides with high functional-group tolerance.
Preliminary mechanistic studies suggest a radical process would be
involved in the catalytic process.
Original language | English |
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Pages (from-to) | 12286-12289 |
Journal | CHEMISTRY-A EUROPEAN JOURNAL |
State | Published - Aug 2016 |