Cobalt-Catalyzed C(sp(2))-H Methylation by using Dicumyl Peroxide as
both the Methylating Reagent and Hydrogen Acceptor

Qun Li; Yanrong Li; Weipeng Hu; Renjian Hu; Guigen Li; Hongjian Lu

Cobalt-Catalyzed C(sp(2))-H Methylation by using Dicumyl Peroxide as both the Methylating Reagent and Hydrogen Acceptor

Qun Li, Yanrong Li, Weipeng Hu, Renjian Hu, Guigen Li, Hongjian Lu

Chemistry and Biochemistry

Research output: Contribution to journal › Article

Abstract

The first cobalt-catalyzed direct methylation of a C(sp(2))-H bond using dicumyl peroxide (DCP) as both the methylating reagent and hydrogen acceptor has been established. The reaction proceeded without the use of any additives, and was proven to be applicable to various amides bearing a 2-pyridinylisopropyl (PIP) directing group, providing an efficient access to o-methyl aryl amides with high functional-group tolerance. Preliminary mechanistic studies suggest a radical process would be involved in the catalytic process.

Original language	English
Pages (from-to)	12286-12289
Journal	CHEMISTRY-A EUROPEAN JOURNAL
State	Published - Aug 2016

Cite this

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title = "Cobalt-Catalyzed C(sp(2))-H Methylation by using Dicumyl Peroxide as both the Methylating Reagent and Hydrogen Acceptor",

abstract = "The first cobalt-catalyzed direct methylation of a C(sp(2))-H bond using dicumyl peroxide (DCP) as both the methylating reagent and hydrogen acceptor has been established. The reaction proceeded without the use of any additives, and was proven to be applicable to various amides bearing a 2-pyridinylisopropyl (PIP) directing group, providing an efficient access to o-methyl aryl amides with high functional-group tolerance. Preliminary mechanistic studies suggest a radical process would be involved in the catalytic process.",

author = "Qun Li and Yanrong Li and Weipeng Hu and Renjian Hu and Guigen Li and Hongjian Lu",

year = "2016",

month = aug,

language = "English",

pages = "12286--12289",

journal = "CHEMISTRY-A EUROPEAN JOURNAL",

issn = "0947-6539",

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TY - JOUR

T1 - Cobalt-Catalyzed C(sp(2))-H Methylation by using Dicumyl Peroxide as both the Methylating Reagent and Hydrogen Acceptor

AU - Li, Qun

AU - Li, Yanrong

AU - Hu, Weipeng

AU - Hu, Renjian

AU - Li, Guigen

AU - Lu, Hongjian

PY - 2016/8

Y1 - 2016/8

N2 - The first cobalt-catalyzed direct methylation of a C(sp(2))-H bond using dicumyl peroxide (DCP) as both the methylating reagent and hydrogen acceptor has been established. The reaction proceeded without the use of any additives, and was proven to be applicable to various amides bearing a 2-pyridinylisopropyl (PIP) directing group, providing an efficient access to o-methyl aryl amides with high functional-group tolerance. Preliminary mechanistic studies suggest a radical process would be involved in the catalytic process.

AB - The first cobalt-catalyzed direct methylation of a C(sp(2))-H bond using dicumyl peroxide (DCP) as both the methylating reagent and hydrogen acceptor has been established. The reaction proceeded without the use of any additives, and was proven to be applicable to various amides bearing a 2-pyridinylisopropyl (PIP) directing group, providing an efficient access to o-methyl aryl amides with high functional-group tolerance. Preliminary mechanistic studies suggest a radical process would be involved in the catalytic process.

M3 - Article

SP - 12286

EP - 12289

JO - CHEMISTRY-A EUROPEAN JOURNAL

JF - CHEMISTRY-A EUROPEAN JOURNAL

SN - 0947-6539

ER -

Cobalt-Catalyzed C(sp(2))-H Methylation by using Dicumyl Peroxide as both the Methylating Reagent and Hydrogen Acceptor

Abstract

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