Cobalt-Catalyzed Cross-Dehydrogenative Coupling Reactions of (Benz)oxazoles with Ethers

Yanrong Li, Mengshi Wang, Wei Fan, Fen Qian, Guigen Li, Hongjian Lu

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


The cobalt-catalyzed cross-dehydrogenative coupling of (benz)oxazoles and ethers is described. Access to some important bioactive heteroaryl ether derivatives was achieved using CoCO3 as an inexpensive catalyst at levels as low as 1.0 mol %. Investigation of the mechanism indicates a catalytic cycle involving a radical process.

Original languageEnglish
Pages (from-to)11743-11750
Number of pages8
JournalJournal of Organic Chemistry
Issue number23
StatePublished - Dec 2 2016


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