Cobalt-Catalyzed Cross-Dehydrogenative Coupling Reaction between Unactivated C(sp2)-H and C(sp3)-H Bonds

Qun Li, Weipeng Hu, Renjian Hu, Hongjian Lu, Guigen Li

Research output: Contribution to journalArticlepeer-review

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Catalytic oxidative cross-dehydrogenative coupling between unactivated C(sp2)-H and C(sp3)-H bonds is achieved by the cobalt-catalyzed o-alkylation reaction of aromatic carboxamides containing (pyridin-2-yl)isopropyl amine (PIP-NH2) as a N,N-bidentate directing group. Many different C(sp3)-H bonds in alkanes, toluene derivatives and even in the α-position of ethers and thioethers can be used as coupling partners. This method has a broad substrate scope and the tolerance of various functional groups.

Original languageEnglish
Pages (from-to)4676-4679
Number of pages4
JournalOrganic Letters
Issue number17
StatePublished - Sep 1 2017


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