Coating formulations for microneedles

Harvinder Gill, M. R. Prausnitz

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE: To develop a rational basis for designing coating solution formulations for uniform and thick coatings on microneedles and to identify coating strategies to form composite coatings, deliver liquid formulations, and control the mass deposited on microneedles. MATERIALS AND METHODS: Microneedles were fabricated using laser-cutting and then dip-coated using different aqueous, organic solvent-based or molten liquid formulations. The mass of riboflavin (vitamin B(2)) coated onto microneedles was determined as a function of coating and microneedle parameters. Coated microneedles were also inserted into porcine cadaver skin to assess delivery efficacy. RESULTS: Sharp-tipped microneedles, including pocketed microneedles, were fabricated. Excipients that reduced coating solution surface tension improved coating uniformity, while excipients that increased solution viscosity improved coating thickness. Evaluation of more than 20 different coating formulations using FDA approved excipien
Original languageEnglish
Pages (from-to)1369-80
JournalPharm Res
StatePublished - 2007

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