Coated microneedles for drug delivery to the eye

J. Jiang; Harvinder Gill; D. Ghate; B. E. McCarey; S. R. Patel; H. F. Edelhauser; M. R. Prausnitz

Coated microneedles for drug delivery to the eye

J. Jiang, Harvinder Gill, D. Ghate, B. E. McCarey, S. R. Patel, H. F. Edelhauser, M. R. Prausnitz

Chemical Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

PURPOSE: To test the hypothesis that coated microneedles can deliver drugs into the eye via intrascleral and intracorneal routes in a minimally invasive manner. METHODS: Solid metal microneedles measuring 500 to 750 microm in length were coated with model drugs, protein, and DNA; inserted into nonpreserved human cadaveric sclera; and imaged. Microneedles coated with sodium fluorescein were then inserted into rabbit cornea in vivo. After needle removal, fluorescein concentration in the anterior segment of the rabbit eye was measured for 24 hours. Similar experiments were performed using pilocarpine-coated microneedles, and the rabbit pupil size was monitored afterward. RESULTS: In vitro insertion tests showed that microneedles were mechanically strong enough to penetrate into human cadaveric sclera and that the drug coating rapidly dissolved off the needles within the scleral tissue within 30 seconds after insertion. In vivo delivery from fluorescein-coated microneedles showed that flu

Original language	English
Pages (from-to)	4038-43
Journal	Invest Ophthalmol Vis Sci
State	Published - 2007

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title = "Coated microneedles for drug delivery to the eye",

abstract = "PURPOSE: To test the hypothesis that coated microneedles can deliver drugs into the eye via intrascleral and intracorneal routes in a minimally invasive manner. METHODS: Solid metal microneedles measuring 500 to 750 microm in length were coated with model drugs, protein, and DNA; inserted into nonpreserved human cadaveric sclera; and imaged. Microneedles coated with sodium fluorescein were then inserted into rabbit cornea in vivo. After needle removal, fluorescein concentration in the anterior segment of the rabbit eye was measured for 24 hours. Similar experiments were performed using pilocarpine-coated microneedles, and the rabbit pupil size was monitored afterward. RESULTS: In vitro insertion tests showed that microneedles were mechanically strong enough to penetrate into human cadaveric sclera and that the drug coating rapidly dissolved off the needles within the scleral tissue within 30 seconds after insertion. In vivo delivery from fluorescein-coated microneedles showed that flu",

author = "J. Jiang and Harvinder Gill and D. Ghate and McCarey, {B. E.} and Patel, {S. R.} and Edelhauser, {H. F.} and Prausnitz, {M. R.}",

year = "2007",

language = "English",

pages = "4038--43",

journal = "Invest Ophthalmol Vis Sci",

}

TY - JOUR

T1 - Coated microneedles for drug delivery to the eye

AU - Jiang, J.

AU - Gill, Harvinder

AU - Ghate, D.

AU - McCarey, B. E.

AU - Patel, S. R.

AU - Edelhauser, H. F.

AU - Prausnitz, M. R.

PY - 2007

Y1 - 2007

N2 - PURPOSE: To test the hypothesis that coated microneedles can deliver drugs into the eye via intrascleral and intracorneal routes in a minimally invasive manner. METHODS: Solid metal microneedles measuring 500 to 750 microm in length were coated with model drugs, protein, and DNA; inserted into nonpreserved human cadaveric sclera; and imaged. Microneedles coated with sodium fluorescein were then inserted into rabbit cornea in vivo. After needle removal, fluorescein concentration in the anterior segment of the rabbit eye was measured for 24 hours. Similar experiments were performed using pilocarpine-coated microneedles, and the rabbit pupil size was monitored afterward. RESULTS: In vitro insertion tests showed that microneedles were mechanically strong enough to penetrate into human cadaveric sclera and that the drug coating rapidly dissolved off the needles within the scleral tissue within 30 seconds after insertion. In vivo delivery from fluorescein-coated microneedles showed that flu

AB - PURPOSE: To test the hypothesis that coated microneedles can deliver drugs into the eye via intrascleral and intracorneal routes in a minimally invasive manner. METHODS: Solid metal microneedles measuring 500 to 750 microm in length were coated with model drugs, protein, and DNA; inserted into nonpreserved human cadaveric sclera; and imaged. Microneedles coated with sodium fluorescein were then inserted into rabbit cornea in vivo. After needle removal, fluorescein concentration in the anterior segment of the rabbit eye was measured for 24 hours. Similar experiments were performed using pilocarpine-coated microneedles, and the rabbit pupil size was monitored afterward. RESULTS: In vitro insertion tests showed that microneedles were mechanically strong enough to penetrate into human cadaveric sclera and that the drug coating rapidly dissolved off the needles within the scleral tissue within 30 seconds after insertion. In vivo delivery from fluorescein-coated microneedles showed that flu

M3 - Article

SP - 4038

EP - 4043

JO - Invest Ophthalmol Vis Sci

JF - Invest Ophthalmol Vis Sci

ER -