Co-crystallization of anti-inflammatory pharmaceutical contaminants and rare carboxylic acid-pyridine supramolecular synthon breakdown

Qixuan Zheng; Samantha L. Rood; Daniel K. Unruh; Kristin M. Hutchins

doi:10.1039/c8ce01492b

Co-crystallization of anti-inflammatory pharmaceutical contaminants and rare carboxylic acid-pyridine supramolecular synthon breakdown

Qixuan Zheng, Samantha L. Rood, Daniel K. Unruh, Kristin M. Hutchins

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The reliability of supramolecular synthons in co-crystals involving naproxen and mefenamic acid is investigated. The carboxylic acid⋯pyridine synthon is exceptionally reliable; however, we observe synthon breakdown and a rare pyridyl dimer in a co-crystal with mefenamic acid. A Cambridge Structural Database survey supports the rarity of this motif in acid-bipyridine co-crystals.

Original language	English
Pages (from-to)	6377-6381
Number of pages	5
Journal	CrystEngComm
Volume	20
Issue number	41
DOIs	https://doi.org/10.1039/c8ce01492b
State	Published - 2018

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abstract = "The reliability of supramolecular synthons in co-crystals involving naproxen and mefenamic acid is investigated. The carboxylic acid⋯pyridine synthon is exceptionally reliable; however, we observe synthon breakdown and a rare pyridyl dimer in a co-crystal with mefenamic acid. A Cambridge Structural Database survey supports the rarity of this motif in acid-bipyridine co-crystals.",

author = "Qixuan Zheng and Rood, {Samantha L.} and Unruh, {Daniel K.} and Hutchins, {Kristin M.}",

year = "2018",

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AU - Zheng, Qixuan

AU - Rood, Samantha L.

AU - Unruh, Daniel K.

AU - Hutchins, Kristin M.

PY - 2018

Y1 - 2018

N2 - The reliability of supramolecular synthons in co-crystals involving naproxen and mefenamic acid is investigated. The carboxylic acid⋯pyridine synthon is exceptionally reliable; however, we observe synthon breakdown and a rare pyridyl dimer in a co-crystal with mefenamic acid. A Cambridge Structural Database survey supports the rarity of this motif in acid-bipyridine co-crystals.

AB - The reliability of supramolecular synthons in co-crystals involving naproxen and mefenamic acid is investigated. The carboxylic acid⋯pyridine synthon is exceptionally reliable; however, we observe synthon breakdown and a rare pyridyl dimer in a co-crystal with mefenamic acid. A Cambridge Structural Database survey supports the rarity of this motif in acid-bipyridine co-crystals.

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DO - 10.1039/c8ce01492b

M3 - Article

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JO - CrystEngComm

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