TY - JOUR
T1 - Chronic effects of methadone on a line tilt generalization gradient in the pigeon
AU - Thompson, Travis
AU - Glenn, Michael
AU - Winston, Neil
AU - Young, Alice M.
N1 - Funding Information:
Among the potentially more interesting properties of any drug are its effects on stimulus control over behavior. While there have been numerous studies of effects of LSD, am- ~This research was supported by research grant DA-00332 from the National Institute of Drug Abuse. The authors wish to acknowledge the assistance of Dr. Richard Malott who provided part of the equipment necessary for the conduct of this research. ~Reprints may be obtained from Dr. Travis Thompson, Department of Psychology, University of Minnesota, Minneapolis, Minnesota 55455. :'During the course of this research, N.W. was supported as a predoctoral research fellow under USPHS Grant MH-08565. ~During the course of this research A.M.Y. was supported as a predoctoral research fellow under USPHS Grant MH-08565 and National Institute of Drug Abuse Grant DA-05028.
PY - 1978/9
Y1 - 1978/9
N2 - Using an adjusting interval schedule, pigeons were trained to key peck at a relatively constant rate during 45° line tilt presentations and at an extremely low rate in the presence of 0° and 90° line angles. Subsequently, the birds received intramuscular injections of methadone hydrochloride every 8 hr in doses beginning at 3 mg/kg/day and increasing progressively to 90 mg/kg/day. Stimulus generalization tests were run on the first day and on the last day a given dose was administered to assess the development of tolerance. Although chronic methadone treatment was associated with an overall decrement in key peck rate, the gradients of line tilt generalization were indistinguishable from saline control gradients as doses as high as 90 mg.kg/day. Though the birds exhibited gross behavioral incoordination, visual stimulus control appeared unaffected.
AB - Using an adjusting interval schedule, pigeons were trained to key peck at a relatively constant rate during 45° line tilt presentations and at an extremely low rate in the presence of 0° and 90° line angles. Subsequently, the birds received intramuscular injections of methadone hydrochloride every 8 hr in doses beginning at 3 mg/kg/day and increasing progressively to 90 mg/kg/day. Stimulus generalization tests were run on the first day and on the last day a given dose was administered to assess the development of tolerance. Although chronic methadone treatment was associated with an overall decrement in key peck rate, the gradients of line tilt generalization were indistinguishable from saline control gradients as doses as high as 90 mg.kg/day. Though the birds exhibited gross behavioral incoordination, visual stimulus control appeared unaffected.
KW - Adjusting interval schedule
KW - Methadone
KW - Stimulus control
KW - Stimulus generalization
UR - http://www.scopus.com/inward/record.url?scp=0018135029&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(78)90294-0
DO - 10.1016/0091-3057(78)90294-0
M3 - Article
C2 - 714983
AN - SCOPUS:0018135029
SN - 0091-3057
VL - 9
SP - 339
EP - 346
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 3
ER -