Chlorella protein hydrolysate attenuates glucose metabolic disorder and fatty liver in high-fat dietinduced obese mice

Naoto Noguchi, Teruyoshi Yanagita, Shaikh Mizanoor Rahman, Yotaro Ando

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Chlorella (Parachlorella beijerinckii) powder is reported to show a preventive effect against metabolic syndromes such as arteriosclerosis, hyperlipidemia, and hypertension. Approximately 60% of the chlorella content is protein. In order to understand the role of chlorella protein, we prepared a chlorella protein hydrolysate (CPH) by protease treatment. Male C57BL/6 mice were divided into three groups: a normal diet group, high-fat diet (HFD) group, and high-fat diet supplemented with CPH (HFD+CPH) group. The CPH administration improved glucose intolerance, insulin sensitivity, and adipose tissue hypertrophy in the high-fat diet-fed mice. In addition, the HFD+CPH group had significantly decreased liver total cholesterol and triglyceride levels compared with those in the HFD group. Furthermore, the HFD+CPH group had a decreased level of monocyte chemotactic protein-1 (MCP-1) in serum and a lower MCP-1 mRNA expression level in adipose tissue compared with the HFD group. The present study suggests that chlorella protein hydrolysate can prevent a high-fat diet-induced glucose disorder and fatty liver by inhibiting adipocyte hypertrophy and reducing the MCP-1 protein and gene expression.

Original languageEnglish
Pages (from-to)613-620
Number of pages8
JournalJournal of Oleo Science
Volume65
Issue number7
DOIs
StatePublished - 2016

Keywords

  • Clilorella protein hydrolysate
  • Fatty liver
  • Glucose
  • MCP-1
  • Obesity

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