@article{11b92d030d4542e5ad00ca1b00cedf2d,
title = "Chiral N-Phosphonyl Imines for an Aza-Morita-Baylis-Hillman Reaction via Group-Assisted Purification (GAP) Chemistry",
abstract = "Seventeen examples of aza-Morita-Baylis-Hillman (aza-MBH) adducts have been synthesized by reacting chiral N-phosphonyl imines with acrylonitrile in good to excellent yields (up to 96%) and high diastereoselectivity (up to 99:1 dr). The synthesis of these adducts followed the method of group-assisted purification (GAP) chemistry, in which the pure aza-MBH products were readily obtained by washing the crude products with cosolvents of hexane and ethyl acetate.",
author = "Bing Yang and Minxing Shen and Xiaozhou Ji and Ziyan Xu and Hao Sun and Bo Jiang and Guigen Li",
note = "Funding Information: We acknowledge the financial support from the National Natural Science Foundation of China (21332005 and 21402087), the Robert A. Welch Foundation (D-1361, USA) and the NIH (R33DA031860, USA). Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",
year = "2016",
month = mar,
day = "18",
doi = "10.1021/acs.joc.6b00049",
language = "English",
volume = "81",
pages = "2488--2493",
journal = "Journal of Organic Chemistry",
issn = "0022-3263",
publisher = "American Chemical Society (ACS)",
number = "6",
}