Abstract
Seventeen examples of aza-Morita-Baylis-Hillman (aza-MBH) adducts have
been synthesized by reacting chiral N-phosphonyl imines with
acrylonitrile in good to excellent yields (up to 96%) and high
diastereoselectivity (up to 99:1 dr). The synthesis of these adducts
followed the method of group-assisted purification (GAP) chemistry, in
which the pure aza-MBH products were readily obtained by washing the
crude products with cosolvents of hexane and ethyl acetate.
| Original language | English |
|---|---|
| Pages (from-to) | 2488-2493 |
| Journal | Journal of Organic Chemistry |
| State | Published - Mar 2016 |