Abstract
Novel chiral N-phosphonyl imines 2 have been designed and synthesized using chiral N-phosphoramide 1. These N-phosphonyl imines have been successfully utilized for asymmetric aza-Darzens reaction and asymmetric aza-Henry reaction. The C2-symmetric chiral auxiliary tolerates oxidation, is not sensitive to racemization and can be recycled for large scale synthesis.
Original language | English |
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Pages (from-to) | 1573-1577 |
Number of pages | 5 |
Journal | Tetrahedron Letters |
Volume | 49 |
Issue number | 10 |
DOIs | |
State | Published - Mar 3 2008 |
Keywords
- Aziridine
- C-Symmetric diamine
- N-Phosphonyl imines
- Phosphoramide
- aza-Darzens reaction
- aza-Henry reaction