Abstract
Novel chiral N-phosphonyl imines 2 have been designed and synthesized using chiral N-phosphoramide 1. These N-phosphonyl imines have been successfully utilized for asymmetric aza-Darzens reaction and asymmetric aza-Henry reaction. The C2-symmetric chiral auxiliary tolerates oxidation, is not sensitive to racemization and can be recycled for large scale synthesis.
| Original language | English |
|---|---|
| Pages (from-to) | 1573-1577 |
| Number of pages | 5 |
| Journal | Tetrahedron Letters |
| Volume | 49 |
| Issue number | 10 |
| DOIs | |
| State | Published - Mar 3 2008 |
Keywords
- Aziridine
- C-Symmetric diamine
- N-Phosphonyl imines
- Phosphoramide
- aza-Darzens reaction
- aza-Henry reaction
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Kattuboina, A., & Li, G. (2008). Chiral N-phosphonyl imine chemistry: new reagents and their applications for asymmetric reactions. Tetrahedron Letters, 49(10), 1573-1577. https://doi.org/10.1016/j.tetlet.2008.01.028