Chiral N-phosphonyl imine chemistry: new reagents and their applications for asymmetric reactions

Adiseshu Kattuboina, Guigen Li

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

Novel chiral N-phosphonyl imines 2 have been designed and synthesized using chiral N-phosphoramide 1. These N-phosphonyl imines have been successfully utilized for asymmetric aza-Darzens reaction and asymmetric aza-Henry reaction. The C2-symmetric chiral auxiliary tolerates oxidation, is not sensitive to racemization and can be recycled for large scale synthesis.

Original languageEnglish
Pages (from-to)1573-1577
Number of pages5
JournalTetrahedron Letters
Volume49
Issue number10
DOIs
StatePublished - Mar 3 2008

Keywords

  • Aziridine
  • C-Symmetric diamine
  • N-Phosphonyl imines
  • Phosphoramide
  • aza-Darzens reaction
  • aza-Henry reaction

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