A series of new chiral syn-α-branched β-amino ketones has been synthesized by reacting chiral phosphonyl imines with ketone-derived enolates. The N-protection group on imine auxiliary was found to be crucial to the asymmetric induction. The absolute stereochemistry has been unambiguously determined by converting a product to a known sample.
- N-phosphonyl imines
- α-alkyl β-amino ketones