Characterization of the prion protein gene in axis deer (Axis axis) and implications for susceptibility to chronic wasting disease

Matthew J. Buchholz, Emily A. Wright, Blake A. Grisham, Robert D. Bradley, Thomas L. Arsuffi, Warren C. Conway

Research output: Contribution to journalArticlepeer-review

Abstract

Axis deer (Axis axis) occur both in captivity and free-ranging populations in portions of North America, but to-date, no data exist pertaining to the species’ susceptibility to CWD. We sequenced the prion protein gene (PRNP) from axis deer. We then compared axis deer PrPC sequences and amino acid polymorphisms to those of CWD susceptible species. A single PRNP allele with no evidence of intraspecies variation was identified in axis deer that indicates axis deer PRNP is most similar to North American elk (Cervus canadensis) PRNP. Therefore, axis deer may be susceptible to CWD. We recommend proactively increasing CWD surveillance for axis deer, particularly where CWD has been detected and axis deer are sympatric with native North American CWD susceptible species.

Original languageEnglish
Pages (from-to)44-52
Number of pages9
JournalPrion
Volume15
Issue number1
DOIs
StatePublished - 2021

Keywords

  • Axis axis
  • axis deer
  • chital
  • chronic wasting disease
  • prion protein
  • prnp
  • prp

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