TY - JOUR
T1 - Characterization of jets for impulsively-started needle-free jet injectors
T2 - Influence of fluid properties
AU - Rohilla, Pankaj
AU - Rane, Yatish S.
AU - Lawal, I.
AU - Le Blanc, Andrew
AU - Davis, Justin
AU - Thomas, James B.
AU - Weeks, Cormak
AU - Tran, Whitney
AU - Fisher, Paul
AU - Broderick, Kate E.
AU - Simmons, Jonathan A.
AU - Marston, Jeremy O.
N1 - Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/10
Y1 - 2019/10
N2 - An experimental study was performed to assess the hydrodynamics of liquid jets used for needle-free injection, where the typical orifice diameter is ~155 μm and velocity is in range of ~ 60–140 m/s. The jet is impulsively started by a spring-piston that forces a plunger through a cartridge filled with the liquid. Liquid exiting the orifice then forms a jet. However, despite a fixed spring force, the jet speed can vary significantly depending on the fluid physical properties - in particular - the effective viscosity. Since in practice a wide range of fluids may be used for injection, we seek herein to study the jet formation and speed for a broad range of fluids, characterized by viscosity or rheological profile. In addition, we also characterize the jet performance with a peak impact force, measured by a dynamic load cell, and ex-vivo injection experiments on porcine tissue. We find that jet speeds and impact forces decrease in a non-linear fashion with increasing viscosity, but that shear-thinning effects are significant and can render high jet speeds (>100 m/s) even for low-shear viscosities μ0~100 Pa.s.
AB - An experimental study was performed to assess the hydrodynamics of liquid jets used for needle-free injection, where the typical orifice diameter is ~155 μm and velocity is in range of ~ 60–140 m/s. The jet is impulsively started by a spring-piston that forces a plunger through a cartridge filled with the liquid. Liquid exiting the orifice then forms a jet. However, despite a fixed spring force, the jet speed can vary significantly depending on the fluid physical properties - in particular - the effective viscosity. Since in practice a wide range of fluids may be used for injection, we seek herein to study the jet formation and speed for a broad range of fluids, characterized by viscosity or rheological profile. In addition, we also characterize the jet performance with a peak impact force, measured by a dynamic load cell, and ex-vivo injection experiments on porcine tissue. We find that jet speeds and impact forces decrease in a non-linear fashion with increasing viscosity, but that shear-thinning effects are significant and can render high jet speeds (>100 m/s) even for low-shear viscosities μ0~100 Pa.s.
KW - Impact force
KW - Liquid jet
KW - Needle-free injection
KW - Rheology
UR - http://www.scopus.com/inward/record.url?scp=85069821114&partnerID=8YFLogxK
U2 - 10.1016/j.jddst.2019.101167
DO - 10.1016/j.jddst.2019.101167
M3 - Article
AN - SCOPUS:85069821114
SN - 1773-2247
VL - 53
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
M1 - 101167
ER -