TY - JOUR
T1 - Cesium Carboxylate-Promoted Iridium Catalyzed C-H Amidation/Cyclization
with 2,2,2-Trichloroethoxycarbonyl Azide
AU - Zhang, Tao
AU - Wang, Zhen
AU - Hu, Xuejiao
AU - Yu, Meng
AU - Deng, Tianning
AU - Li, Guigen
AU - Lu, Hongjian
PY - 2016/6
Y1 - 2016/6
N2 - An Ir(III)-catalyzed direct C-H amidation/cyclization of benzamides
using 2,2,2-trichloroethoxycarbonyl azide (TrocN3) as the aminocarbonyl
source is reported. With the aid of cesium carboxylate, the reactions
proceed efficiently and with high regioselectivity, producing various
functionalized quinazoline-2,4(1H,3H)-diones, which are important
building blocks and key synthetic intermediates for biologically and
medicinally important compounds. During the reactions, two new C-N bonds
were formed by breaking C-H and N-H bonds sequence.
AB - An Ir(III)-catalyzed direct C-H amidation/cyclization of benzamides
using 2,2,2-trichloroethoxycarbonyl azide (TrocN3) as the aminocarbonyl
source is reported. With the aid of cesium carboxylate, the reactions
proceed efficiently and with high regioselectivity, producing various
functionalized quinazoline-2,4(1H,3H)-diones, which are important
building blocks and key synthetic intermediates for biologically and
medicinally important compounds. During the reactions, two new C-N bonds
were formed by breaking C-H and N-H bonds sequence.
M3 - Article
SP - 4898
EP - 4905
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
SN - 0022-3263
ER -