Cell electroporation model using voronoi networks

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A simulation study to probe cell membrane electroporation in clusters by a highintensity, nanosecond voltage pulse is presented. The focus is on assessing effects associated with the variability in shape and randomness of the cells within clusters, the effects on heterogeneous tissues, and the electric strength versus pulse duration behavior. A two-dimensional Voronoi network approach is used to obtain quantitative, time-dependent results for the cluster collection. The method takes account of the random structure in terms of cell shape and heterogeneous tissue placement. Results demonstrate that in an inhomogeneous system containing a connected mass of tumor cells, electroporation is likely to start at the periphery of the unhealthy cells within the tissue. This arises from the difference in electrical properties between normal/healthy and tumor cells. Simulations also show that the time for poration is the largest for the configurations having the lowest disorder.

Original languageEnglish
Title of host publicationHandbook of Electroporation
PublisherSpringer International Publishing
Pages1287-1302
Number of pages16
Volume2
ISBN (Electronic)9783319328867
ISBN (Print)9783319328850
DOIs
StatePublished - Aug 25 2017

Keywords

  • Biological membranes
  • Electric fields
  • Electroporation
  • Pulse
  • Voronoi network

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    Hu, Q., & Joshi, R. P. (2017). Cell electroporation model using voronoi networks. In Handbook of Electroporation (Vol. 2, pp. 1287-1302). Springer International Publishing. https://doi.org/10.1007/978-3-319-32886-7_141