Catalytic Sulfur-Enabled Dehydrobicyclization of 1,6-Enynes toward Arylated Indeno[1,2-c]thiophenes

Ya Nan Wu, Rong Fu, Nan Nan Wang, Wen Juan Hao, Guigen Li, Shu Jiang Tu, Bo Jiang

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

A new copper-catalyzed sulfur-enabled dehydrobicyclization of 1,6-enynes using potassium sulfide as a sulfurating reagent has been established, providing a straightforward access toward arylated indeno[1,2-c]thiophenes with moderate to good yields. This sulfur incorporation pathway involves Michael addition, 5-exo-dig/5-endo-trig bicyclization and dehydrogenation sequence, resulting in continuous multiple bond-forming events including C-S and C-C bonds to rapidly construct functional organic molecules.

Original languageEnglish
Pages (from-to)4762-4770
Number of pages9
JournalJournal of Organic Chemistry
Volume81
Issue number11
DOIs
StatePublished - Jun 3 2016

Fingerprint Dive into the research topics of 'Catalytic Sulfur-Enabled Dehydrobicyclization of 1,6-Enynes toward Arylated Indeno[1,2-c]thiophenes'. Together they form a unique fingerprint.

Cite this