Catalytic Sulfur-Enabled Dehydrobicyclization of 1,6-Enynes toward Arylated Indeno[1,2-c]thiophenes

Ya Nan Wu, Rong Fu, Nan Nan Wang, Wen Juan Hao, Guigen Li, Shu Jiang Tu, Bo Jiang

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A new copper-catalyzed sulfur-enabled dehydrobicyclization of 1,6-enynes using potassium sulfide as a sulfurating reagent has been established, providing a straightforward access toward arylated indeno[1,2-c]thiophenes with moderate to good yields. This sulfur incorporation pathway involves Michael addition, 5-exo-dig/5-endo-trig bicyclization and dehydrogenation sequence, resulting in continuous multiple bond-forming events including C-S and C-C bonds to rapidly construct functional organic molecules.

Original languageEnglish
Pages (from-to)4762-4770
Number of pages9
JournalJournal of Organic Chemistry
Issue number11
StatePublished - Jun 3 2016


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