Catalytic Sulfur-Enabled Dehydrobicyclization of 1,6-Enynes toward
Arylated Indeno[1,2-c]thiophenes

Ya-Nan Wu; Rong Fu; Nan-Nan Wang; Wen-Juan Hao; Guigen Li; Shu-Jiang Tu; Bo Jiang

Catalytic Sulfur-Enabled Dehydrobicyclization of 1,6-Enynes toward Arylated Indeno[1,2-c]thiophenes

Ya-Nan Wu, Rong Fu, Nan-Nan Wang, Wen-Juan Hao, Guigen Li, Shu-Jiang Tu, Bo Jiang

Chemistry and Biochemistry

Research output: Contribution to journal › Article

Abstract

A new copper-catalyzed sulfur-enabled dehydrobicyclization of 1,6-enynes using potassium sulfide as a sulfurating reagent has been established, providing a straightforward access toward arylated indeno[1,2-c]thiophenes with moderate to good yields. This sulfur incorporation pathway involves Michael addition, 5-exo-dig/S-endo-trig bicyclization and dehydrogenation sequence, resulting in continuous multiple bond-forming events including C-S and C-C bonds to rapidly construct functional organic molecules.

Original language	English
Pages (from-to)	4762-4770
Journal	Journal of Organic Chemistry
State	Published - Jun 2016

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@article{643bde77dbd64f61bceb4861550c6602,

title = "Catalytic Sulfur-Enabled Dehydrobicyclization of 1,6-Enynes toward Arylated Indeno[1,2-c]thiophenes",

abstract = "A new copper-catalyzed sulfur-enabled dehydrobicyclization of 1,6-enynes using potassium sulfide as a sulfurating reagent has been established, providing a straightforward access toward arylated indeno[1,2-c]thiophenes with moderate to good yields. This sulfur incorporation pathway involves Michael addition, 5-exo-dig/S-endo-trig bicyclization and dehydrogenation sequence, resulting in continuous multiple bond-forming events including C-S and C-C bonds to rapidly construct functional organic molecules.",

author = "Ya-Nan Wu and Rong Fu and Nan-Nan Wang and Wen-Juan Hao and Guigen Li and Shu-Jiang Tu and Bo Jiang",

year = "2016",

month = jun,

language = "English",

pages = "4762--4770",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

}

TY - JOUR

T1 - Catalytic Sulfur-Enabled Dehydrobicyclization of 1,6-Enynes toward Arylated Indeno[1,2-c]thiophenes

AU - Wu, Ya-Nan

AU - Fu, Rong

AU - Wang, Nan-Nan

AU - Hao, Wen-Juan

AU - Li, Guigen

AU - Tu, Shu-Jiang

AU - Jiang, Bo

PY - 2016/6

Y1 - 2016/6

N2 - A new copper-catalyzed sulfur-enabled dehydrobicyclization of 1,6-enynes using potassium sulfide as a sulfurating reagent has been established, providing a straightforward access toward arylated indeno[1,2-c]thiophenes with moderate to good yields. This sulfur incorporation pathway involves Michael addition, 5-exo-dig/S-endo-trig bicyclization and dehydrogenation sequence, resulting in continuous multiple bond-forming events including C-S and C-C bonds to rapidly construct functional organic molecules.

AB - A new copper-catalyzed sulfur-enabled dehydrobicyclization of 1,6-enynes using potassium sulfide as a sulfurating reagent has been established, providing a straightforward access toward arylated indeno[1,2-c]thiophenes with moderate to good yields. This sulfur incorporation pathway involves Michael addition, 5-exo-dig/S-endo-trig bicyclization and dehydrogenation sequence, resulting in continuous multiple bond-forming events including C-S and C-C bonds to rapidly construct functional organic molecules.

M3 - Article

SP - 4762

EP - 4770

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

SN - 0022-3263

ER -