@article{6357280157894617ad76ddeed86c54c6,
title = "Catalytic Oxidative Carbene Coupling of α-Diazo Carbonyls for the Synthesis of β-Amino Ketones via C(sp3)-H Functionalization",
abstract = "A catalytic domino oxidative carbene coupling (OCC) of α-diazo carbonyls has been established by treatment with N,N-dimethylanilines and carboxylic acids (or N-methylaniline) via direct C(sp3)-H functionalization under convenient conditions. The reaction pathway is proposed to proceed through the sequence of carbene formation, enolization, and nucleophilic addition. The reaction enables de-diazotized carbo-oxygenation and carbo-amination of α-diazo carbonyls and provides practical access to α-(acyloxy)-β-amino ketones and α,β-diamino ketones.",
author = "Zhang, {Tian Shu} and Hao, {Wen Juan} and Wang, {Nan Nan} and Guigen Li and Jiang, {Dong Fang} and Tu, {Shu Jiang} and Bo Jiang",
note = "Funding Information: We are grateful for financial support from the NSFC (Nos. 21232004, 21332005, and 21472071), PAPD of Jiangsu Higher Education Institutions, the Robert A. Welch Foundation (D- 1361, USA), the NIH (R33DA031860, USA), the Outstanding Youth Fund of JSNU (YQ2015003), NSF of Jiangsu Province (BK20151163), NSF of JSNU (14XLR005), the Qing Lan Project and NSF of Jiangsu Education Committee (15KJB150006), and the Graduate Education Innovation Project of Jiangsu Province (No. KYZZ15-0385). Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",
year = "2016",
month = jul,
day = "1",
doi = "10.1021/acs.orglett.6b01189",
language = "English",
volume = "18",
pages = "3078--3081",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society (ACS)",
number = "13",
}