Catalytic Dual 1,1-H-Abstraction/Insertion for Domino Spirocyclizations

Jiang Kai Qiu, Bo Jiang, Yi Long Zhu, Wen Juan Hao, De Cai Wang, Jun Sun, Ping Wei, Shu Jiang Tu, Guigen Li

Research output: Contribution to journalArticlepeer-review

159 Scopus citations


A catalytic domino spirocyclization of 1,7-enynes with simple cycloalkanes and cyclo-1,3-dicarbonyls has been established via multiple C-C bond formations from alkynyl/alkenyl functions and dual α,α-C(sp3)-H abstraction/insertion. The reaction involves addition, 6-exo-dig cyclization and radical coupling sequences under convenient catalytic conditions and provides a concise access to spiro cyclopenta[c]quinolines in good to excellent yields.

Original languageEnglish
Pages (from-to)8928-8931
Number of pages4
JournalJournal of the American Chemical Society
Issue number28
StatePublished - Jul 22 2015


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