Abstract
An unusual catalytic double [2 + 2] cycloaddition relay reaction of yne-allenones with unactivated alkenes and alkynes has been achieved, which enabled C-C triple-bond cleavage to access more than 60 examples of functionalized phenanthren-9-ols with generally good yields. This reaction provides a regioselective and practical method for the construction of carbocyclic ring systems with a high degree of functional group compatibility. Aside from surveying the scope of this transformation, mechanistic details of this process are provided by conducting systematic theoretical calculations.
Original language | English |
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Pages (from-to) | 4362-4366 |
Number of pages | 5 |
Journal | Organic Letters |
Volume | 20 |
Issue number | 14 |
DOIs | |
State | Published - Jul 20 2018 |