Abstract
The direct arylation of aliphatic aldehydes has been established via
Pd-catalyzed sp(3) C-H bond functionalization in the presence of
3-aminopropanoic acids as transient directing gronps. The reaction
showed excellent functional group compatibility and chemoselectivity in
which a predominant preference for functionalizing unactivated beta-C-H
bonds of methyl groups over others was athieved. In addition, C-H bonds
of unactivated secondary sp(3) carbons can also lie functionalized. The
extreme popularity and importance of aliphatic aldehydes would result in
broad applications of this novel method in organic chemistry and
medicinal sciences.
| Original language | English |
|---|---|
| Pages (from-to) | 12775-12778 |
| Journal | Journal of the American Chemical Society |
| State | Published - Oct 2016 |
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Cite this
Yang, R., Li, Q., Liu, Y., Li, G., & Ge, H. (2016). Catalytic C-H Arylation of Aliphatic Aldehydes Enabled by a Transient
Ligand. Journal of the American Chemical Society, 12775-12778.