Catalytic C-H Arylation of Aliphatic Aldehydes Enabled by a Transient Ligand

Ke Yang, Qun Li, Yongbing Liu, Guigen Li, Haibo Ge

Research output: Contribution to journalArticlepeer-review

140 Scopus citations


The direct arylation of aliphatic aldehydes has been established via Pd-catalyzed sp3 C-H bond functionalization in the presence of 3-aminopropanoic acids as transient directing groups. The reaction showed excellent functional group compatibility and chemoselectivity in which a predominant preference for functionalizing unactivated β-C-H bonds of methyl groups over others was achieved. In addition, C-H bonds of unactivated secondary sp3 carbons can also be functionalized. The extreme popularity and importance of aliphatic aldehydes would result in broad applications of this novel method in organic chemistry and medicinal sciences.

Original languageEnglish
Pages (from-to)12775-12778
Number of pages4
JournalJournal of the American Chemical Society
Issue number39
StatePublished - Oct 5 2016


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