Catalytic asymmetric addition of arylboronic acids to isatins using C 2-symmetric cationic N -heterocyclic carbenes (NHCs) Pd2+ diaqua complexes as catalysts

Zhen Liu, Peng Gu, Min Shi, Patrick McDowell, Guigen Li

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Abstract

Chemical equations presented. A catalytic asymmetric addition of arylboronic acids to isatins has been achieved by using chiral cationic C 2-symmetric N-heterocyclic carbene (NHC) Pd2+ diaqua complexes as the catalysts. The reaction can be performed under convenient conditions to give the corresponding adducts in good to high yields (79-94%) and moderate to excellent enantioselectivities (up to 94% ee) in the presence of LiOAr as the promoter which was generated in situ.

Original languageEnglish
Pages (from-to)2314-2317
Number of pages4
JournalOrganic Letters
Volume13
Issue number9
DOIs
StatePublished - May 6 2011

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