Catalyst-free aminobromination of alkenes with N-methyl-p-toluenesulfonamide as nitrogen resource

Guangqian Zhang, Guanghui An, Jun Zheng, Yi Pan, Guigen Li

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

A catalyst-free electrophilic aminobromination system was described with N-methyl-p-toluenesulfonamide (p-TsNHCH3) and N-bromosuccinimide (NBS) as nitrogen and bromine resources. The reaction can give vicinal haloamines in good yields, excellent regioselectivities, and stereoselectivities under convenient and mild condition. The existence of N-methyl group in the nitrogen resource was found to play an important role in the formation of vicinal haloamine product.

Original languageEnglish
Pages (from-to)987-989
Number of pages3
JournalTetrahedron Letters
Volume51
Issue number6
DOIs
StatePublished - Feb 10 2010

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