Cascade bicyclizations of o-alkynyl aldehydes with thiazolium salts: A new access toward poly-functionalized indeno[2,1-b]pyrroles

Peng Zhou, Wen Juan Hao, Jin Peng Zhang, Bo Jiang, Guigen Li, Shu Jiang Tu

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A new cascade bicyclization of o-alkynyl aldehydes with thiazolium salts is described, in which 25 examples of densely functionalized indeno[2,1-b]pyrroles are achieved in a functional-group-compatible manner. Thiazole carbenes generated in situ from thiazolium salts play dual roles as reaction partners and as NHC catalysts. The synthetic utility of these bicyclization reactions results in subsequent C-C bond-forming events to rapidly build up molecular complexity.

Original languageEnglish
Pages (from-to)13012-13015
Number of pages4
JournalChemical Communications
Issue number65
StatePublished - Aug 21 2015


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