TY - JOUR
T1 - Carboxylate-Assisted Iridium-Catalyzed C-H Amination of Arenes with
Biologically Relevant Alkyl Azides
AU - Zhang, Tao
AU - Hu, Xuejiao
AU - Wang, Zhen
AU - Yang, Tiantian
AU - Sun, Hao
AU - Li, Guigen
AU - Lu, Hongjian
N1 - Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2016/2
Y1 - 2016/2
N2 - An iridium-catalyzed C-H amination of arenes with a wide substrate scope
is reported. Benzamides with electron-donating and -withdrawing groups
and linear, branched, and cyclic alkyl azides are all applicable. Cesium
carboxylate is crucial for both reactivity and regioselectivity of the
reactions. Many biologically relevant molecules, such as amino acid,
peptide, steroid, sugar, and thymidine derivatives can be introduced to
arenes with high yields and 100% chiral retention.
AB - An iridium-catalyzed C-H amination of arenes with a wide substrate scope
is reported. Benzamides with electron-donating and -withdrawing groups
and linear, branched, and cyclic alkyl azides are all applicable. Cesium
carboxylate is crucial for both reactivity and regioselectivity of the
reactions. Many biologically relevant molecules, such as amino acid,
peptide, steroid, sugar, and thymidine derivatives can be introduced to
arenes with high yields and 100% chiral retention.
M3 - Article
AN - SCOPUS:84960981750
SN - 0947-6539
SP - 2920
EP - 2924
JO - CHEMISTRY-A EUROPEAN JOURNAL
JF - CHEMISTRY-A EUROPEAN JOURNAL
ER -