Calculation of Liquid-Disordered/Liquid-Ordered Line Tension from Pairwise Lipid Interactions

J. Huang, S. Hiraki, G. W. Feigenson

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The energy penalty for bilayer phase domain interfaces, line tension, is an important quantity for describing the phase domain size transition from the nanometer scale to the micrometer scale and larger. We connected pairwise lipid interaction energies in ternary lipid mixtures with experimentally measured line tensions by using the compositional differences between coexisting liquid-disordered (Ld) and liquid-ordered (Lo) phases known from phase diagrams. Using a mean-field theory model, we developed a computational procedure to map out Ld + Lo phase boundaries and thermodynamic tielines based on a set of pairwise interaction energies. We find that experimentally measured Ld/Lo line tension can be effectively modeled by the sum of pairwise interactions at the interface. This result indicates that pairwise lipid interactions make a major contribution to line tension.

Original languageEnglish
Pages (from-to)4949-4959
Number of pages11
JournalJournal of Physical Chemistry B
Issue number24
StatePublished - Jun 18 2020


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