Cadmium-Induced Changes in Deer Mouse Seminiferous Tubules

Angella Gentles, Bernard Tandler, Ernest Smith

Research output: Contribution to journalArticlepeer-review


Abstract Twenty-four male deer mice, 10-12 wks old, were exposed to drinking water containing cadmium chloride (CdCl2) at 20 ppm for 30 days. At that point, the weighed mice were sacrificed and the testes removed, weighed, and processed for routine histologic evaluation. Compared to control animals, there was no change in the body or testis weights of mice exposed to CdCl2. Tailless spermatozoa were observed in some seminiferous tubules of testis from CdCl2-treated mice. Some tubules of CdCl2-treated mice displayed exaggerated intercellular spaces; in certain tubules, this cellular separation was profound. There appeared to be a reduction in the number of Sertoli cells. Keywords: cadmium, seminiferous tubules, testis, spermatogenesis
Original languageEnglish
Pages (from-to)593-595
JournalToxicological and Enviromental Chemistry
StatePublished - Feb 2012


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