Cadmium-induced changes in deer mouse seminiferous tubules

Angella Gentles, Bernard Tandler, Ernest E. Smith

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Twenty-four male deer mice, 10-12 weeks old, were exposed to drinking water containing cadmium chloride (CdCl 2) at 20 ppm for 30 days. At that point, the weighed mice were sacrificed and testes were excised, weighed, and processed for routine histologic evaluation. Compared to control animals, there was no change in the body or testis weights of mice exposed to CdCl 2. Tailless spermatozoa were observed in some seminiferous tubules of testes from CdCl 2-treated mice. Some tubules of CdCl 2-treated mice displayed exaggerated intercellular spaces; in certain tubules, this cellular separation was profound. There appeared to be a reduction in the number of Sertoli cells.

Original languageEnglish
Pages (from-to)593-595
Number of pages3
JournalToxicological and Environmental Chemistry
Volume94
Issue number3
DOIs
StatePublished - Mar 2012

Keywords

  • cadmium
  • seminiferous tubules
  • spermatogenesis
  • testis

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