TY - JOUR
T1 - Cadmium-induced changes in deer mouse seminiferous tubules
AU - Gentles, Angella
AU - Tandler, Bernard
AU - Smith, Ernest E.
PY - 2012/3
Y1 - 2012/3
N2 - Twenty-four male deer mice, 10-12 weeks old, were exposed to drinking water containing cadmium chloride (CdCl 2) at 20 ppm for 30 days. At that point, the weighed mice were sacrificed and testes were excised, weighed, and processed for routine histologic evaluation. Compared to control animals, there was no change in the body or testis weights of mice exposed to CdCl 2. Tailless spermatozoa were observed in some seminiferous tubules of testes from CdCl 2-treated mice. Some tubules of CdCl 2-treated mice displayed exaggerated intercellular spaces; in certain tubules, this cellular separation was profound. There appeared to be a reduction in the number of Sertoli cells.
AB - Twenty-four male deer mice, 10-12 weeks old, were exposed to drinking water containing cadmium chloride (CdCl 2) at 20 ppm for 30 days. At that point, the weighed mice were sacrificed and testes were excised, weighed, and processed for routine histologic evaluation. Compared to control animals, there was no change in the body or testis weights of mice exposed to CdCl 2. Tailless spermatozoa were observed in some seminiferous tubules of testes from CdCl 2-treated mice. Some tubules of CdCl 2-treated mice displayed exaggerated intercellular spaces; in certain tubules, this cellular separation was profound. There appeared to be a reduction in the number of Sertoli cells.
KW - cadmium
KW - seminiferous tubules
KW - spermatogenesis
KW - testis
UR - http://www.scopus.com/inward/record.url?scp=84859199927&partnerID=8YFLogxK
U2 - 10.1080/02772248.2012.658664
DO - 10.1080/02772248.2012.658664
M3 - Article
AN - SCOPUS:84859199927
VL - 94
SP - 593
EP - 595
JO - Toxicological and Environmental Chemistry
JF - Toxicological and Environmental Chemistry
SN - 0277-2248
IS - 3
ER -