TY - JOUR
T1 - Building Congested Ketone
T2 - Substituted Hantzsch Ester and Nitrile as Alkylation Reagents in Photoredox Catalysis
AU - Chen, Wenxin
AU - Liu, Zheng
AU - Tian, Jiaqi
AU - Li, Jin
AU - Ma, Jing
AU - Cheng, Xu
AU - Li, Guigen
N1 - Publisher Copyright:
© 2016 American Chemical Society.
PY - 2016/9/28
Y1 - 2016/9/28
N2 - For the first time, 4-alkyl Hantzsch esters were used to construct molecules with all-carbon quaternary centers by visible light-induced photoredox catalysis via transfer alkylation. Up to a 1500 h-1 turnover frequency was achieved in this reaction. Reactions of 4-alkyl Hantzsch nitriles as tertiary radical donors joined two contiguous all-carbon quaternary centers intermolecularly, and this chemistry was used to synthesize a common precursor of a class of hydroxysteroid dehydrogenase inhibitors.
AB - For the first time, 4-alkyl Hantzsch esters were used to construct molecules with all-carbon quaternary centers by visible light-induced photoredox catalysis via transfer alkylation. Up to a 1500 h-1 turnover frequency was achieved in this reaction. Reactions of 4-alkyl Hantzsch nitriles as tertiary radical donors joined two contiguous all-carbon quaternary centers intermolecularly, and this chemistry was used to synthesize a common precursor of a class of hydroxysteroid dehydrogenase inhibitors.
UR - http://www.scopus.com/inward/record.url?scp=84989235793&partnerID=8YFLogxK
U2 - 10.1021/jacs.6b06379
DO - 10.1021/jacs.6b06379
M3 - Article
AN - SCOPUS:84989235793
VL - 138
SP - 12312
EP - 12315
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
SN - 0002-7863
IS - 38
ER -