Building Congested Ketone: Substituted Hantzsch Ester and Nitrile as Alkylation Reagents in Photoredox Catalysis

Wenxin Chen, Zheng Liu, Jiaqi Tian, Jin Li, Jing Ma, Xu Cheng, Guigen Li

Research output: Contribution to journalArticle

Abstract

For the first time, 4-alkyl Hantzsch esters were used to construct molecules with all-carbon quaternary centers by visible light-induced photoredox catalysis via transfer alkylation. Up to a 1500 h(-1) turnover frequency was achieved in this reaction. Reactions of 4-alkyl Hantzsch nitriles as tertiary radical donors joined two contiguous all-carbon quaternary centers intermolecularly, and this chemistry was used to synthesize a common precursor of a class of hydroxysteroid dehydrogenase inhibitors.
Original languageEnglish
Pages (from-to)12312-12315
JournalJournal of the American Chemical Society
StatePublished - Sep 2016

Fingerprint Dive into the research topics of 'Building Congested Ketone: Substituted Hantzsch Ester and Nitrile as Alkylation Reagents in Photoredox Catalysis'. Together they form a unique fingerprint.

  • Cite this