TY - JOUR
T1 - BST-2/tetherin
T2 - A new component of the innate immune response to enveloped viruses
AU - Evans, David T.
AU - Serra-Moreno, Ruth
AU - Singh, Rajendra K.
AU - Guatelli, John C.
N1 - Funding Information:
This research was supported by Public Health Service grants AI087498, AI063993 and RR000168 to D.T.E. and AI081668 to J.C.G. D.T.E. is an Elizabeth Glaser Scientist supported by the Elizabeth Glaser Pediatric AIDS Foundation.
PY - 2010/9
Y1 - 2010/9
N2 - The interferon-inducible, transmembrane protein BST-2 (CD317, tetherin) directly holds fully formed enveloped virus particles to the cells that produce them, inhibiting their spread. BST-2 inhibits members of the retrovirus, filovirus, arenavirus and herpesvirus families. These viruses encode a variety of proteins to degrade BST-2 and/or direct it away from its site of action at the cell surface. Viral antagonism has subjected BST-2 to positive selection, leading to species-specific differences that presented a barrier to the transmission of simian immunodeficiency viruses (SIVs) to humans. This barrier was crossed by HIV-1 when its Vpu protein acquired activity as a BST-2 antagonist. Here, we review this new host-pathogen relationship and discuss its impact on the evolution of primate lentiviruses and the origins of the HIV pandemic.
AB - The interferon-inducible, transmembrane protein BST-2 (CD317, tetherin) directly holds fully formed enveloped virus particles to the cells that produce them, inhibiting their spread. BST-2 inhibits members of the retrovirus, filovirus, arenavirus and herpesvirus families. These viruses encode a variety of proteins to degrade BST-2 and/or direct it away from its site of action at the cell surface. Viral antagonism has subjected BST-2 to positive selection, leading to species-specific differences that presented a barrier to the transmission of simian immunodeficiency viruses (SIVs) to humans. This barrier was crossed by HIV-1 when its Vpu protein acquired activity as a BST-2 antagonist. Here, we review this new host-pathogen relationship and discuss its impact on the evolution of primate lentiviruses and the origins of the HIV pandemic.
UR - http://www.scopus.com/inward/record.url?scp=77956188831&partnerID=8YFLogxK
U2 - 10.1016/j.tim.2010.06.010
DO - 10.1016/j.tim.2010.06.010
M3 - Review article
C2 - 20688520
AN - SCOPUS:77956188831
SN - 0966-842X
VL - 18
SP - 388
EP - 396
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 9
ER -