An assumed displacement hybrid finite-element method suitable for finite-elastic deformation of anisotropic material was developed. This numerical procedure was then used to determine the strain distribution in the vicinity of a blunt indenter applied to the exposed surface of the pia-arachnoid of an anesthetized rhesus monkey. A comparison of the numerical results and neuro-pathological results indicates that a maximum strain of 0. 2 similar 0. 4 is necessary for the brain cells to retain the effect of indentation.