Blocking FSH induces thermogenic adipose tissue and reduces body fat

Peng Liu, Yaoting Ji, Tony Yuen, Elizabeth Rendina-Ruedy, Victoria E. Demambro, Samarth Dhawan, Wahid Abu-Amer, Sudeh Izadmehr, Bin Zhou, Andrew C. Shin, Rauf Latif, Priyanthan Thangeswaran, Animesh Gupta, Jianhua Li, Valeria Shnayder, Samuel T. Robinson, Yue Eric Yu, Xingjian Zhang, Feiran Yang, Ping LuYu Zhou, Ling Ling Zhu, Douglas J. Oberlin, Terry F. Davies, Michaela R. Reagan, Aaron Brown, T. Rajendra Kumar, Solomon Epstein, Jameel Iqbal, Narayan G. Avadhani, Maria I. New, Henrik Molina, Jan B. Van Klinken, Edward X. Guo, Christoph Buettner, Shozeb Haider, Zhuan Bian, Li Sun, Clifford J. Rosen, Mone Zaidi

Research output: Contribution to journalArticlepeer-review

134 Scopus citations

Abstract

Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal antibody that targets the β-subunit of the pituitary hormone follicle-stimulating hormone (Fsh) increases bone mass in mice. Here, we report that this antibody sharply reduces adipose tissue in wild-type mice, phenocopying genetic haploinsufficiency for the Fsh receptor gene Fshr. The antibody also causes profound beiging, increases cellular mitochondrial density, activates brown adipose tissue and enhances thermogenesis. These actions result from the specific binding of the antibody to the β-subunit of Fsh to block its action. Our studies uncover opportunities for simultaneously treating obesity and osteoporosis.

Original languageEnglish
Pages (from-to)107-112
Number of pages6
JournalNature
Volume546
Issue number7656
DOIs
StatePublished - Jun 1 2017

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