Biomaterials for induction and treatment of autoimmunity

Akhilesh Kumar Shakya, Kutty Selva Nandakumar

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations

Abstract

Use of biomaterials in autoimmunity research is widely explored, as an adjuvant to induce antigen specific immune responses, for facilitating induction of experimental models to study disease pathogenesis and for designing novel therapeutic targets. Similarly, polymeric biomaterials are explored as a delivery vehicle for sustained and specific release of auto-antigens/drugs to treat autoimmune disorders. Although considered as biocompatible, implantation/injection of polymers like silica and metallic implants are associated with development of chronic inflammation and autoimmunity. Despite these compatibility concerns, biomaterials are still considered as favorable materials for several applications in the autoimmunity field.

Original languageEnglish
Title of host publicationAdvanced Structured Materials
PublisherSpringer-Verlag
Pages167-184
Number of pages18
DOIs
StatePublished - Jan 1 2017

Publication series

NameAdvanced Structured Materials
Volume66
ISSN (Print)1869-8433
ISSN (Electronic)1869-8441

Keywords

  • Arthritis
  • Auto-antigen specific immunotherapy
  • Autoimmunity
  • Biomaterials
  • Poly-N-isopropylacrylamide
  • Polymer

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