Bioinformatics protocols in glycomics and glycoproteomics

Haixu Tang, Anoop Mayampurath, Chuan Yih Yu, Yehia Mechref

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Glycomics aims to identify the whole set of functional glycans of glycoconjugates (attached to proteins or lipids) in biological samples. Glycoproteomics aims to characterize the complete structure of all glycoproteins in biological samples, including the glycosylation sites of proteins and the various glycan structures attached to each of these sites. Mass spectrometry (MS) and microarray are high-throughput technologies that are commonly used in glycomics and glycoproteomics, which often result in the generation of large experimental datasets. Bioinformatics approaches play an essential role in automated analysis and interpretation of such data. This unit describes and discusses the computational tools currently available for these analyses, and their glycomics and glycoproteomics applications.

Original languageEnglish
Article number2.15
JournalCurrent Protocols in Protein Science
Issue numberSUPPL.76
DOIs
StatePublished - 2014

Keywords

  • Bioinformatics
  • Glycomics
  • Glycoproteomics
  • Glycosylation
  • Mass spectrometry
  • Microarray

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