TY - JOUR
T1 - Biocompatible swelling graphene oxide reinforced double network hydrogels with high toughness and stiffness
AU - Wang, Jilong
AU - Su, Siheng
AU - Qiu, Jingjing
N1 - Publisher Copyright:
© The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2017.
PY - 2017
Y1 - 2017
N2 - Tough swelling nanocomposite hydrogels have been fabricated via introducing graphene oxide (GO) and in situ synthesis. Upon addition of GO, the swelling properties of a calcium alginate/polyacrylamide (CA/PAAm) double network (DN) are considerably suppressed. Moreover, the mechanical properties of CA/PAAm DN gels and GO reinforced DN gels in swelling and as-prepared states have been systematically explored. The results affirm that the swelling largely damages the mechanical properties of gels, due to the osmotic pressure introducing solvents into the gaps between polymer chains and cross-linkers, thereby leading to weak spots in the gels. GO demonstrates the ability to improve the mechanical properties of pristine DN gels in both swelling and as-prepared states by offering large numbers of physical interpenetrations and chemical bindings between long polymeric chains and GO nanosheets, and building a Ca2+ coordination-induced GO network. The toughness of swelling nanocomposite gels is around 106 kJ m-3 that is comparable to that of cartilage in large animal joints. Furthermore, the consecutive loading-unloading tests and cytotoxicity tests show that the swelling nanocomposite gels, respectively, obtain superior fatigue resistance and high biocompatibility. Therefore, these swelling nanocomposite gels are promising as substitutes for load-bearing tissues.
AB - Tough swelling nanocomposite hydrogels have been fabricated via introducing graphene oxide (GO) and in situ synthesis. Upon addition of GO, the swelling properties of a calcium alginate/polyacrylamide (CA/PAAm) double network (DN) are considerably suppressed. Moreover, the mechanical properties of CA/PAAm DN gels and GO reinforced DN gels in swelling and as-prepared states have been systematically explored. The results affirm that the swelling largely damages the mechanical properties of gels, due to the osmotic pressure introducing solvents into the gaps between polymer chains and cross-linkers, thereby leading to weak spots in the gels. GO demonstrates the ability to improve the mechanical properties of pristine DN gels in both swelling and as-prepared states by offering large numbers of physical interpenetrations and chemical bindings between long polymeric chains and GO nanosheets, and building a Ca2+ coordination-induced GO network. The toughness of swelling nanocomposite gels is around 106 kJ m-3 that is comparable to that of cartilage in large animal joints. Furthermore, the consecutive loading-unloading tests and cytotoxicity tests show that the swelling nanocomposite gels, respectively, obtain superior fatigue resistance and high biocompatibility. Therefore, these swelling nanocomposite gels are promising as substitutes for load-bearing tissues.
UR - http://www.scopus.com/inward/record.url?scp=85021960561&partnerID=8YFLogxK
U2 - 10.1039/c6nj03791g
DO - 10.1039/c6nj03791g
M3 - Article
AN - SCOPUS:85021960561
SN - 1144-0546
VL - 41
SP - 3781
EP - 3789
JO - New Journal of Chemistry
JF - New Journal of Chemistry
IS - 10
ER -